New Research Challenges Common Beliefs About Processed Fats and Heart Health
A groundbreaking study from King's College London and Maastricht University offers surprising reassurance about certain processed fats commonly found in everyday foods. The research reveals that interesterified fats made from palm or plant oils didn't raise cholesterol levels or cause metabolic harm in healthy adults when consumed in normal dietary amounts. This challenges the widespread belief that all processed fats are dangerous and demonstrates how food technology can safely replace harmful trans fats in products like baked goods, margarines, and spreads.
Recent nutritional science has delivered a surprising twist in the ongoing debate about processed foods and heart health. A comprehensive study conducted by researchers from King's College London and Maastricht University provides compelling evidence that challenges conventional wisdom about certain types of processed fats. The findings, published in the American Journal of Clinical Nutrition, suggest that not all industrially processed fats deserve the negative reputation they've acquired in recent years.

Understanding Interesterified Fats
Interesterified fats represent a specific category of processed fats that have become increasingly important in food manufacturing. These fats are created through a chemical process called interesterification, which rearranges the fatty acids on the glycerol backbone of fat molecules. This process allows manufacturers to create solid fats with specific functional properties without relying on harmful trans fats or excessive amounts of traditional saturated fats.
The study focused specifically on two types of interesterified fats: those rich in palmitic acid (sourced from palm oil) and those rich in stearic acid (derived from other plant fats). Both types are commonly used in food products like margarines, baked goods, pastries, and confectionery items where solid fat functionality is required for texture and stability.
Study Methodology and Design
The research employed a rigorous double-blind randomized crossover trial design, considered the gold standard in nutritional research. Forty-seven healthy adults participated in the study, each following two separate six-week diets that included specially formulated muffins and spreads containing either palmitic acid-rich or stearic acid-rich interesterified fats.

These fats provided approximately 10% of the participants' total daily energy intake, representing realistic consumption levels that people might achieve through normal dietary patterns. The double-blind design ensured that neither participants nor researchers knew which type of fat was being consumed during each phase, eliminating potential bias in the results.
Key Findings and Health Implications
The comprehensive assessment of cardiometabolic health markers revealed no meaningful differences between the two types of interesterified fats across multiple health indicators. Most importantly, researchers found no significant changes in blood cholesterol levels, including the crucial ratio of total to HDL cholesterol, which serves as a key measure of cardiovascular risk.
Beyond cholesterol measurements, the study also examined triglycerides, insulin sensitivity, liver fat accumulation, inflammation markers, and blood vessel function. Across all these parameters, the interesterified fats showed no signs of causing metabolic harm or increasing risk factors for heart disease during the six-week intervention period.
Expert Perspectives on the Results
Professor Sarah Berry, senior author and Professor of Nutritional Sciences at King's College London, emphasized the importance of these findings in the context of current food processing debates. "With the current demonization of everything processed, this research highlights that not all food processing is bad for us!" she stated. "The process of interesterification allows the generation of hard fats in place of harmful trans fats, whilst also enabling manufacturers to reduce the saturated fat content of spreads and foods."

Professor Wendy Hall, lead author and Professor of Nutritional Sciences at King's College London, provided additional context: "Our findings provide reassuring evidence that industrially processed fats currently used in everyday foods, whether rich in palmitic or stearic acid, are unlikely to have harmful effects on cardiovascular health when consumed in amounts that people could achieve in their everyday diets."
Practical Implications for Consumers and Industry
These findings have significant implications for both food manufacturers and health-conscious consumers. For the food industry, the research validates the safety of using interesterified fats as alternatives to trans fats, which have been largely phased out due to their well-established cardiovascular risks. This provides manufacturers with scientifically supported options for creating products with desirable textures and stability while maintaining food safety.
For consumers, the study offers reassurance that not all processed ingredients in packaged foods necessarily pose health risks. However, experts caution that this doesn't mean all ultra-processed foods are automatically healthy. The research specifically addresses interesterified fats consumed in normal amounts as part of a balanced diet, not the overall nutritional profile of heavily processed food products.
Limitations and Future Research Directions
While the six-week study duration was sufficient to detect meaningful changes in cholesterol and related metabolic markers, the researchers acknowledge that longer-term studies are needed to fully understand potential effects over extended periods. Future research should also explore how these fats might affect different population groups, including those with existing metabolic conditions or genetic predispositions to cardiovascular disease.
The study was conducted jointly by King's College London and Maastricht University with support from the Malaysian Palm Oil Board, highlighting the international collaboration in modern nutritional science. As research in this field continues to evolve, consumers can expect more nuanced understanding of how different food processing techniques impact health.
Conclusion
This groundbreaking research from King's College London and Maastricht University represents an important step forward in understanding the complex relationship between food processing and health. By demonstrating that specific interesterified fats don't negatively impact heart health markers in healthy adults, the study challenges blanket assumptions about processed foods and provides valuable insights for both nutritional science and food manufacturing practices.
As Professor Berry aptly summarized, "Given the widespread use of the process of interesterification of fats and the fearmongering around food processing, this research is timely." The findings remind us that nutritional science continues to evolve, and that careful, evidence-based evaluation of specific food components is essential for making informed dietary choices.





