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NFL Week 17 Odds: A Complete Betting Guide for the 2025 Season's Pivotal Matchups

The 2025 NFL season reaches a critical juncture in Week 17, with playoff implications on the line. This guide provides a comprehensive breakdown of the betting odds, point spreads, and moneylines for all 16 matchups, including the Christmas Day triple-header. We analyze key lines from DraftKings Sportsbook, highlight potential value bets, and explain the betting terminology essential for navigating this high-stakes week of professional football.

The final stretch of the 2025 NFL regular season is here, and Week 17 presents a slate of games with immense consequences for playoff seeding and postseason berths. Betting lines for these matchups offer a quantitative lens through which to view each team's perceived strength and the expected competitiveness of the games. This guide breaks down the odds for every Week 17 contest, providing clarity for fans and bettors navigating this pivotal week.

NFL football on field with stadium lights
NFL game action under stadium lights.

Understanding Week 17 Betting Lines

Before diving into the specific matchups, it's crucial to understand the key betting terms. The point spread is the number of points by which a favored team is expected to win. Betting on the favorite requires them to win by more than that number, while betting on the underdog means they must either win outright or lose by fewer than the spread. The moneyline represents the odds for a team to win the game outright, with negative numbers indicating the favorite and positive numbers the underdog. The over/under (O/U) is the projected total combined points scored by both teams.

Christmas Day Triple-Header: Opening Act Results

Week 17 kicked off with a festive triple-header on December 25th. According to the lines from DraftKings Sportsbook, the Dallas Cowboys were favored by 7 points over the Washington Commanders, with the total set at 50.5 points. The Detroit Lions were heavy favorites at -7.5 against the Minnesota Vikings (O/U 43.5), and the Denver Broncos were massive 13.5-point favorites hosting the Kansas City Chiefs in a game with a low total of 36.5 points.

Dallas Cowboys helmet
Dallas Cowboys team helmet.

Saturday and Sunday Slate: Key Matchups and Lines

The action continues on Saturday, December 27th, with two intriguing games. The Los Angeles Chargers are slight 1.5-point favorites at home against the Houston Texans, with a tight moneyline (Texans +110, Chargers -130) and a low over/under of 39.5 points. Later, the Green Bay Packers host the Baltimore Ravens as 4.5-point favorites, also with a total set at 39.5 points.

Sunday, December 28th, features a full day of 11 games with varying degrees of competitiveness. Several teams are significant favorites, including the New England Patriots (-13.5 vs. NY Jets), the Jacksonville Jaguars (-5.5 at Indianapolis Colts), and the Cincinnati Bengals (-7.5 vs. Arizona Cardinals). Other contests are projected to be much closer, such as the New Orleans Saints at Tennessee Titans (-2.5), the New York Giants at Las Vegas Raiders (-1.5), and the Philadelphia Eagles at Buffalo Bills (-1.5). The highest over/under of the week is 53.5 points for the Cardinals-Bengals game, while the lowest is 34.5 for the Pittsburgh Steelers at Cleveland Browns matchup.

Green Bay Packers logo at Lambeau Field
Green Bay Packers logo and stadium.

Monday Night Football Finale

Week 17 concludes on Monday, December 29th, with the Los Angeles Rams visiting the Atlanta Falcons. The Rams are substantial 7.5-point favorites in this contest, with a total points line set at 49.5.

Betting Considerations for Week 17

Week 17 is unique due to variable team motivations. Some clubs may be locked into their playoff position and could rest key starters, while others will be fighting for their postseason lives. This dynamic can create value opportunities or significant risk, making it essential to monitor team news and official injury reports leading up to kickoff. The lines provided offer a snapshot of market expectations, but astute bettors will factor in these intangible elements before placing any wagers.

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